Current Update of Patient-Derived Xenograft Model for Translational Breast Cancer Research
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چکیده
منابع مشابه
Patient-Derived Xenograft (PDX) Models: An Emerging Platform for Cancer Drug Development and Translational Research
Previously, cancer drug development was an arena that relied almost exclusively on transgenic and severely compromised immuno-deficient (SCID) mice to measure tumor growth in response to novel therapeutic drugs. Development has now evolved to the point where several different murine models are now employed. The industry has expanded to include syngeneic and humanized mice, in addition to PDX mo...
متن کاملPatient-derived xenograft models: an emerging platform for translational cancer research.
UNLABELLED Recently, there has been an increasing interest in the development and characterization of patient-derived tumor xenograft (PDX) models for cancer research. PDX models mostly retain the principal histologic and genetic characteristics of their donor tumor and remain stable across passages. These models have been shown to be predictive of clinical outcomes and are being used for precl...
متن کاملPatient-derived xenograft in zebrafish embryos: a new platform for translational research in gastric cancer
BACKGROUND Gastric cancer (GC) is among the most commonly cancer occurred in Asian, especially in China. With its high heterogeneity and few of validated drug targets, GC remains to be one of the most under explored areas of precision medicine. In this study, we aimed to establish an in vivo patient-derived xenograft (PDX) model based on zebrafish (Danio rerio) embryos, allowing for a rapid ana...
متن کاملTranslational pancreatic cancer research: A comparative study on patient-derived xenograft models
AIM To assess the viability of orthotopic and heterotopic patient-derived pancreatic cancer xenografts implanted into nude mice. METHODS This study presents a prospective experimental analytical follow-up of the development of tumours in mice upon implantation of human pancreatic adenocarcinoma samples. Specimens were obtained surgically from patients with a pathological diagnosis of pancreat...
متن کاملCurrent status and perspectives of patient-derived xenograft models in cancer research
Cancers remain a major public health problem worldwide, which still require profound research in both the basic and preclinical fields. Patient-derived xenograft (PDX) models are created when cancerous cells or tissues from patients' primary tumors are implanted into immunodeficient mice to simulate human tumor biology in vivo, which have been extensively used in cancer research. The routes of ...
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ژورنال
عنوان ژورنال: Journal of Mammary Gland Biology and Neoplasia
سال: 2017
ISSN: 1083-3021,1573-7039
DOI: 10.1007/s10911-017-9378-7